Ross, H. E. and Cole, C. D. and Smith, Y. and Neumann, I. D. and Landgraf, R. and Murphy, A. Z. and Young, L. J. (2009) CHARACTERIZATION OF THE OXYTOCIN SYSTEM REGULATING AFFILIATIVE BEHAVIOR IN FEMALE PRAIRIE VOLES. NEUROSCIENCE, 162 (4). pp. 892-903. ISSN 0306-4522, 1873-7544
Full text not available from this repository. (Request a copy)Abstract
Oxytocin regulates partner preference formation and alloparental behavior in the socially monogamous prairie vole (Microtus ochrogaster) by activating oxytocin receptors in the nucleus accumbens of females. Mating facilitates partner preference formation, and oxytocin-immunoreactive fibers in the nucleus accumbens have been described in prairie voles. However, there has been no direct evidence of oxytocin release in the nucleus accumbens during sociosexual interactions, and the origin of the oxytocin fibers is unknown. Here we show for the first time that extracellular concentrations of oxytocin are increased in the nucleus accumbens of female prairie vole during unrestricted interactions with a male. We further show that the distribution of oxytocin-immunoreactive fibers in the nucleus accumbens is conserved in voles, mice and rats, despite remarkable species differences in oxytocin receptor binding in the region. Using a combination of site-specific and peripheral infusions of the retrograde tracer Fluorogold, we demonstrate that the nucleus accumbens oxytocin-immunoreactive fibers likely originate from paraventricular and supraoptic hypothalamic neurons. This distribution of retrogradely labeled neurons is consistent with the hypothesis that striatal oxytocin fibers arise from collaterals of magnocellular neurons of the neurohypophysial system. If correct, this may serve to coordinate peripheral and central release of oxytocin with appropriate behavioral responses associated with reproduction, including pair bonding after mating, and maternal responsiveness following parturition and during lactation. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VAGINOCERVICAL STIMULATION; MATERNAL-BEHAVIOR; NUCLEUS-ACCUMBENS; SPINAL-CORD; RAT-BRAIN; MICROTUS-OCHROGASTER; CEREBROSPINAL-FLUID; CENTRAL VASOPRESSIN; POLYGAMOUS VOLES; RECEPTOR DENSITY; pair bonding; nucleus accumbens; paraventricular nucleus; supraoptic nucleus; neurohypophysial peptides; alloparental behavior |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Sep 2020 07:09 |
| Last Modified: | 07 Sep 2020 07:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/28404 |
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