Haertel, Christoph and Haase, Berit and Browning-Carmo, Kathryn and Gebauer, Corinna and Kattner, Evelyn and Kribs, Angela and Segerer, Hugo and Teig, Norbert and von der Wense, Axel and Wieg, Christian and Herting, Egbert and Goepel, Wolfgang (2009) Does the Enteral Feeding Advancement Affect Short-term Outcomes in Very Low Birth Weight Infants? JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 48 (4). pp. 464-470. ISSN 0277-2116, 1536-4801
Full text not available from this repository. (Request a copy)Abstract
Background and Objectives: Controversy exists regarding the optimal enteral feeding regimen of very low birth weight infants (VLBW). Rapid advancement of enteral feeding has been associated with an increased rate of necrotizing enterocolitis. In contrast, delaying enteral feeding may have unfavorable effects on nutrition, growth, and neurodevelopment. The aim is to compare the short-term outcomes of VLBW infants in tertiary care centers according to their enteral feeding advancement. Patients and Methods: We prospectively studied the influence of center-specific enteral feeding advancement in 1430 VLBW infants recruited from 13 tertiary neonatal intensive care units in Germany on short-term outcome parameters. The centers were post hoc stratified to "rapid advancement to full enteral feeds" (median duration of advancement to full enteral feeds <= 12.5 days; 6 centers), that is, rapid advancement (RA), or "slow advancement to full enteral feeds" (median duration of advancement to full enteral feeds > 12.5 days; 7 centers), that is, slow advancement (SA). Results: VLBW infants born in centers with SA (n = 713) had a significantly higher rate of sepsis compared with VLBW infants born in centers with RA (n = 717), which was particularly evident for late-onset sepsis (14.0% vs 20.4%; P = 0.002). Furthermore, more central venous lines (48.6% vs 31.1%, P < 0.001) and antibiotics (92.4% vs 77.7%, P < 0.001) were used in centers with SA. Conclusions: Center differences in enteral feeding advancement occur and may have a significant impact on short-term outcomes such as nosocomial sepsis. Large, multicenter, prospective trials are required to further elucidate the optimal feeding strategy for VLBW infants. JPGN 48:464-470, 2009.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEGATIVE STAPHYLOCOCCAL BACTEREMIA; NECROTIZING ENTEROCOLITIS; GASTRIC RESIDUALS; PRETERM INFANTS; ASSOCIATION; SEPSIS; TRIAL; SLOW; Central lines; Enteral feeding; Gram negative; Gram positive; Sepsis; VLBW |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Sep 2020 14:20 |
| Last Modified: | 18 Sep 2020 14:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29189 |
Actions (login required)
 |
View Item |
