Reber, Stefano O. and Obermeier, Florian and Straub, Rainer H. and Veenema, Alexa H. and Neumann, Inga D. (2009) Aggravation of DSS-induced colitis after chronic subordinate colony (CSC) housing is partially mediated by adrenal mechanisms. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 12 (5). pp. 225-234. ISSN 1025-3890,
Full text not available from this repository. (Request a copy)Abstract
Chronic subordinate colony housing (CSC) is a relevant chronic psycho-social stressor for male mice. Here, we investigated effects of CSC on the severity of dextran sulphate sodium (DSS)-induced colitis and the involvement of adrenal mechanisms. After 19 days of CSC, male C57BL/6 mice were treated with 1% DSS (8 days). After 8 days, inflammatory shortening of the colon and the histological inflammation score were increased in CSC mice. Additionally, the increased secretion of pro-inflammatory cytokines by mesenteric lymph node cells found on day 2 and 4 of DSS treatment was down-regulated in CSC mice on day 8 of DSS treatment, paralleled by an increase in plasma corticosterone. In contrast, in unstressed controls, elevation of cytokine secretion was delayed and only found on day 8 of DSS treatment, associated with a prompt rise in plasma corticosterone. To reveal adrenal mechanisms in CSC-induced effects on colitis, mice were adrenalectomized, exposed to CSC and treated with DSS (8 days). In adrenalectomized CSC mice, the severity of DSS-induced colitis was reduced, as body weight loss, shortening of colon, histological damage score, and cytokine secretion from mesenteric lymph node cells were diminished compared with sham-operated CSC mice. In conclusion, exposure to chronic psycho-social stress increases the severity of acute DSS colitis, an effect which is, at least partly, mediated by adrenal mechanisms.
Item Type: | Article |
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Uncontrolled Keywords: | DEXTRAN SULFATE SODIUM; INFLAMMATORY BOWEL-DISEASE; ULCERATIVE-COLITIS; ENDOGENOUS GLUCOCORTICOIDS; INTERFERON-GAMMA; ACUTE STRESS; PLUS-MAZE; MICE; RAT; INTERLEUKIN-10; Adrenal insufficiency; chronic psycho-social stress; colitis; corticosterone; chronic subordinate colony (CSC) housing; inflammation |
Subjects: | 500 Science > 590 Zoological sciences 600 Technology > 610 Medical sciences Medicine |
Divisions: | Medicine > Lehrstuhl für Innere Medizin I Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
Depositing User: | Dr. Gernot Deinzer |
Date Deposited: | 14 Oct 2020 05:55 |
Last Modified: | 14 Oct 2020 05:55 |
URI: | https://pred.uni-regensburg.de/id/eprint/29892 |
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