Denzinger, S. and Burger, M. and Fritsche, H. -M. and Ganzer, R. and Blana, A. and Wieland, W. F. and Otto, Wolfgang (2008) Bladder preservation or initial cystectomy in T1G3 bladder cancer: Which parameters help in therapeutic decision-making? AKTUELLE UROLOGIE, 39 (1). pp. 58-61. ISSN 0001-7868,
Full text not available from this repository. (Request a copy)Abstract
Purpose: T1G3 bladder cancers show the clinical and biological behaviour of muscle invasive tumours with progression rates of about 30%. While radical cystectomy in some cases is indicated, other patients can achieve heating with organ preservation. We present a study anallysing the influence of the risk factors multifocality, tumour diameter > 3 cm and associated carcinoma in situ (Cis) on the outcome of initial T1G3 bladder cancers treated in various ways. Materials and Methods: Of 223 patients with initial T1G3 bladder cancer, 125 patients underwent transurethral resection of the tumour JURB), second resection and adjuvant bacille Calmette-Guerin (BCG) instillations (TURB group), 98 patients chose initial radical cystectomy (CX group). Results: Median follow-up times were 56 months JURB group) and 51 months (CX group). 5- and 10-year survival rates (82% and 65% in TURB group vs. 75% and 48% in CX group) did not show statistically significant differences. In Cox regression analysis no single risk factor showed a prognostic value. While in TURB group the combination of all risk factors (multifocality, tumour diameter >= 3 cm and associated carcinoma in situ) was associated with a statistically significantly lower survival rate, the same combination in the CX group was not oncologically relevant. Conclusions: While initial T1G3 bladder cancer with up to two risk factors after organ-preserving therapy is not associated with a lower tumour specific survival rate in comparison to radical cystectomy, patients with a combination of the three analysed risk factors would profit by an early radical cystectomy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; BACILLUS-CALMETTE-GUERIN; RADICAL CYSTECTOMY; FOLLOW-UP; PROGRESSION; RECURRENCE; SURVIVAL; bladder carcinoma; T1G3; transurethral resection; radical cystectomy; risk factors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Nov 2020 08:04 |
| Last Modified: | 11 Nov 2020 08:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/31529 |
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