Neumeier, Markus and Sigruener, Alexander and Eggenhofer, Elke and Weigert, Johanna and Weiss, Thomas S. and Schaeffler, Andreas and Schlitt, Hans J. and Aslanidis, Charalampos and Piso, Pompillu and Langmann, Thomas and Schmitz, Gerd and Schoelmerich, Juergen and Buechler, Christa (2007) High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 352 (2). pp. 543-548. ISSN 0006-291X,
Full text not available from this repository. (Request a copy)Abstract
Low circulating levels of high molecular weight adiponectin (HMW-Apm) have been linked to dyslipidaemia and systemic HMW-Apm negatively correlates with very low density lipoprotein (VLDL), apolipoprotein B (ApoB), and ApoE and is positively associated with ApoA-I. Therefore, it was investigated whether HMW-Apm alters the hepatic synthesis of ApoB, ApoE, and ApoA-I or the activity of the hepatic ATP-binding cassette transporter A1 (ABCA1), as the main determinant of plasma HDL. HMW-Apm reduces hepatic ApoB and ApoE release whereas ABCA1 protein, activity and ApoA-I were not altered. Global gene expression analysis revealed that hepatic nuclear factor 4-alpha (HNF4-alpha) and HNF4-alpha regulated genes like ApoB are downregulated by HMW-Apm and this was confirmed at the mRNA and protein level. Therefore it is concluded that HMW-adiponectin may ameliorate dyslipidaemia by reducing the hepatic release of ApoB and ApoE, whereas ABCA1 function and ApoA-I secretion are not influenced. (c) 2006 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | METABOLIC SYNDROME; NUCLEAR FACTOR-4-ALPHA; CHOLESTEROL; GENE; MICE; EXPRESSION; SECRETION; TRANSPORT; ABCA1; ATHEROSCLEROSIS; dyslipidaemia; apolipoprotein B; ATP-binding cassette transporter A1; hepatic nuclear factor 4-alpha; adiponectin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Dec 2020 07:53 |
| Last Modified: | 23 Dec 2020 07:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33296 |
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