Wolff, Johannes E. A. and Wagner, Sabine and Reinert, Christiane and Gnekow, Astrid and Kortmann, R. -D. and Kuehl, Joachim and Van Gool, Stefaan W. (2006) Maintenance treatment with interferon-gamma and low-dose cyclophosphamide for pediatric high-grade glioma. JOURNAL OF NEURO-ONCOLOGY, 79 (3). pp. 315-321. ISSN 0167-594X,
Full text not available from this repository. (Request a copy)Abstract
Background The prognosis of high-grade glioma in children is poor. Purpose Interferon-gamma may increase the immune surveillance of glioma cells. Earlier clinical evidence had shown that low dose cyclophosphamide (CPM) increased immune response. Methods After induction treatment with simultaneous radiation and chemotherapy, patients were treated with individually increasing interferon-gamma (IFN-gamma) doses starting from 25 mu g/m(2)/ d s.c. increasing up to a maximum of 175 mu g/m(2)/ d within 7 weeks. Cyclophosphamide was given at 300 mg/m(2) i.v. every 21 days. Forty pediatric glioma patients were enrolled ( median age: 8.5 year, male: n = 22). Tumor locations included cerebral cortex ( n = 8), basal ganglia ( n = 4), brainstem ( n = 24), cerebellum ( n = 3), spinal cord ( n = 1). Histologies were GBM ( n = 14), AA ( n = 14), LGG ( n = 2, diffuse intrinsic pontine glioma). There was grade IV toxicity for thrombocytopenia (10%) and leucopenia (2.5%), grade III toxicity for central nervous ( 2.5%) and hepatic (5%) side effects, no toxic death. The observation time of the six surviving patients was: 1.2, 1.9, 4.2, 4.4, 4.6 and 4.7 years respectively. The median overall survival ( 1 year) was not significantly different from a historical control group (0.8 years). The survival of pontine gliomas appeared even inferior when compared to the previous protocol ( n. s.). Conclusion Maintenance treatment with IFN-gamma and low dose CPM has no sufficient beneficial effect for the treatment of high-grade glioma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN GLIOBLASTOMA CELLS; INHIBITS PROLIFERATION; IFN-GAMMA; IN-VITRO; T-CELLS; EXPRESSION; ADHESION; IMMUNOTHERAPY; LYMPHOCYTES; ASTROCYTES; IFN-gamma; children; glioma; cyclophosphamide; pons |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jan 2021 13:10 |
| Last Modified: | 27 Jan 2021 13:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34108 |
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