Haertel, Christoph and Koenig, Inke and Koester, Stefan and Kattner, Evelyn and Kuhls, Eckhardt and Kuester, Helmut and Moeller, Jens and Mueller, Dirk and Kribs, Angela and Segerer, Hugo and Wieg, Christian and Herting, Egbert and Goepel, Wolfgang (2006) Genetic polymorphisms of hemostasis genes and primary outcome of very low birth weight infants. PEDIATRICS, 118 (2). 683-U68. ISSN 0031-4005,
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND. Recent investigations have reported an influence of thrombophilic mutations and antithrombotic risk factors with development of intraventricular hemorrhage. It was our objective for this study to investigate the impact of genetic polymorphisms of hemostasis genes on the primary outcome measures of sepsis, bronchopulmonary dysplasia, intraventricular hemorrhage, and periventricular leukomalacia in a large cohort of very low birth weight infants. METHODS. There were 586 very low birth weight infants enrolled prospectively in a multicenter trial between September 2003 and July 2005, and an additional 595 very low birth weight infants, who had been recruited in a previous prospective trial, were studied. DNA samples were taken by buccal swab, and genotypes of factor V Leiden mutation, prothrombin G20210A mutation, the factor VII-323 del/ins polymorphism, and the factor XIII-Val34Leu polymorphisms were determined by polymerase chain reaction and restriction enzyme digestion. RESULTS. In contrast to data published previously, the frequency of intraventricular hemorrhage or periventricular leukomalacia was not significantly influenced by any of the genetic variants tested. Carriers of the factor XIII-Val34Leu polymorphism, however, had a higher sepsis rate and a longer period of hospital care compared with noncarriers. The factor VII-323 del/ins polymorphism was found to be a potential protective factor against bronchopulmonary dysplasia. CONCLUSIONS. We could not confirm previously reported associations of hemostasis gene variants and development of intraventricular hemorrhage in very low birth weight infants. To better understand gene-disease associations in very low birth weight infants, the prospective development of large-scale cohorts with well-defined phenotypes and corresponding DNA samples is essential.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR-XIII GENE; FACTOR-VII GENE; FACTOR-V-LEIDEN; VENOUS THROMBOSIS; VAL34LEU POLYMORPHISM; MYOCARDIAL-INFARCTION; PRETERM INFANTS; INTRAVENTRICULAR HEMORRHAGE; INTRACRANIAL HEMORRHAGE; COMMON POLYMORPHISM; VLBW; outcome; hemostasis genes; polymorphism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Feb 2021 11:49 |
| Last Modified: | 09 Feb 2021 11:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34255 |
Actions (login required)
 |
View Item |
