Goepel, W and Hartel, C and Ahrens, P and Konig, I and Kattner, E and Kuhls, E and Kuster, H and Moller, J and Muller, D and Roth, B and Segerer, H and Wieg, C and Herting, E (2006) Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants. GENES AND IMMUNITY, 7 (1). pp. 65-68. ISSN 1466-4879,
Full text not available from this repository. (Request a copy)Abstract
We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6174CC- genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6174GG (n = 430) 8%, IL-6-174GC ( n = 605) 9% and IL-6-174CC ( n = 167) 12% ( P = 0.2 for IL-6-174CC vs GG+GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19% of IL-6-174GG-carriers ( n = 157), 26% of IL-6-174GC-carriers ( n = 193) and 27% of infants carrying the IL-6-174CC- genotype ( n 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROMOTER POLYMORPHISM; ASSOCIATION; ADULTS; GENES; IL-6; preterm infants; interleukin 6; intraventricular hemorrhage; sepsis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2021 11:17 |
| Last Modified: | 01 Mar 2021 11:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35156 |
Actions (login required)
 |
View Item |
