Promm, M. and Schroeder, A. and Neissner, C. and Eder, F. and Roesch, W. H. and Schroeder, J. (2016) Acquired cryptorchidism: More harm than thought? JOURNAL OF PEDIATRIC UROLOGY, 12 (4): 236.e1. ISSN 1477-5131, 1873-4898
Full text not available from this repository. (Request a copy)Abstract
Introduction Acquired cryptorchidism (AC) has been recognized as a subgroup of undescended testes (UDT). There is growing evidence that the compromising effect equals that of congenital UDT (cUDT). This prospective study included an extensive histological examination of biopsies taken from AC patients. Patients and methods From August 2013 to December 2014, 21 boys (3-12 years of age) underwent testicular biopsy during orchiopexy for AC. Patient and family histories were taken. The amount of germ cells ( GC) per tubule (T) and the amount of adult dark spermatogonia (Ad-S) per T were determined by resin semi-thin sections examination. The samples were also scanned for signs of malformation. Immunohistochemical stains were performed as markers for atypical germ cells. Results Four (19%) boys were born prematurely, two (9.5%) were small for gestational age (SGA), and nine (43%) had a positive family history of UDT. The median of GC/T was 1.06 in boys <9 years, and 0.60 in boys >= 9 years. The median of Ad-S/T was 0.02 in boys <9 years and 0.01 in boys >= 9 years. There were no signs for malformation and no atypical cells. The immunohistochemical stains were negative in all specimens. Conclusions Prematurity, SGA, and a positive family history appeared to be predictors for AC. Extensive histopathological examination of AC revealed a significant reduction of germ cell count and fertility markers, comparable with that in cUDT. The alterations were more severe in boys aged >= 9 years. It is unclear as to whether or not this was possibly caused by a longer duration of inguinal position, but this finding suggests that routine checks of testicular position throughout childhood are needed, and that there is a cause for continued efforts in educating parents and primary care physicians regarding AC. Current data support the notion of surgical correction once the diagnosis is made.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UNDESCENDED TESTIS; ASCENDING TESTIS; FERTILITY; BOYS; MANAGEMENT; POSITION; SURGERY; DESCENT; BIRTH; RISK; Acquired cryptorchidism; Congenital cryptorchidism; Fertility; Germ cells; Ascensus testis; Undescended testes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Apr 2019 08:59 |
| Last Modified: | 03 Apr 2019 08:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3524 |
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