Rutkowski, S. and De Vleeschouwer, S. and Kaempgen, E and Wolff, J. E. A. and Kuhl, J. and Demaerel, P. and Warmuth-Metz, M. and Flamen, P. and Van Calenbergh, F. and Plets, C. and Sorensen, N. and Opitz, A. and Van Gool, S. W. (2004) Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study. BRITISH JOURNAL OF CANCER, 91 (9). pp. 1656-1662. ISSN 0007-0920, 1532-1827
Full text not available from this repository. (Request a copy)Abstract
Patients with relapsed malignant glioma have a poor prognosis. We developed a strategy of vaccination using autologous mature dendritic cells loaded with autologous tumour homogenate. In total, 12 patients with a median age of 36 years (range: 11-78) were treated. All had relapsing malignant glioma. After surgery, vaccines were given at weeks 1 and 3, and later every 4 weeks. A median of 5 (range: 2-7) vaccines was given. There were no serious adverse events except in one patient with gross residual tumour prior to vaccination, who repetitively developed vaccine-related peritumoral oedema. Minor toxicities were recorded in four out of 12 patients. In six patients with postoperative residual tumour, vaccination induced one stable disease during 8 weeks, and one partial response. Two of six patients with complete resection are in CCR for 3 years. Tumour vaccination for patients with relapsed malignant glioma is feasible and likely beneficial for patients with minimal residual tumour burden.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHASE-II TRIAL; GLIOBLASTOMA-MULTIFORME; IMMUNE-RESPONSES; IMMUNOTHERAPY; ANTIGEN; CANCER; GENERATION; CHILDHOOD; CARCINOMA; glioma; immunotherapy; tumour vaccination; dendritic cells; adjuvant therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jun 2021 12:33 |
| Last Modified: | 22 Jun 2021 12:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36987 |
Actions (login required)
 |
View Item |
