Geis, T. and Peters, O. and Friedrich, M. and Draenert, E. and Wolff, Johannes E. A. (2004) Brief report - Intratumoral methotrexate kinetics in a patient with intracranial anaplastic ependymoma. PEDIATRIC BLOOD & CANCER, 43 (1). pp. 78-80. ISSN 1545-5009, 1545-5017
Full text not available from this repository. (Request a copy)Abstract
Little is known about intratumoral anticancer drug concentration in childhood brain tumors. We were able to measure methotrexate (MTX) tumor concentrations directly in a cystic anaplastic ependymoma. Cyst fluid was obtained by puncture of a subgaleal Rickham reservoir connected to a catheter in the tumor cyst. MTX concentrations were determined by fluorescence polarization immunoassay and compared to serum concentrations. Maximum MTX concentrations in tumor and CSF were found at the end of MTX infusion. Twenty-four hour after MTX infusion the mean turner concentration was significantly higher than in the serum indicating MTX retention and accumulation in the tumor cyst. An AUC(tumour)/AUC(serum) ratio of 1.95 was obtained. In response to the applied multiagent chemotherapy the clinical condition of our patient improved and the tumor showed partial response on MRI. Cystic ependymomas might benefit from high dose MTX especially because of drug retention in the tumor cyst. (C) 2004 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CEREBROSPINAL-FLUID; CHILDHOOD; childhood cancer; ependymoma; methotrexate; pharmacokinetics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Jul 2021 09:29 |
| Last Modified: | 12 Jul 2021 09:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37514 |
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