Brunner, Henri and Arndt, M. R. and Treittinger, B. (2004) Porphyrin platinum conjugates - new aims. INORGANICA CHIMICA ACTA, 357 (6). pp. 1649-1669. ISSN 0020-1693
Full text not available from this repository. (Request a copy)Abstract
Forty porphyrin platinum conjugates were synthesized, which exhibited a photodynamic effect due to the porphyrin system and a cytostatic effect due to the platinum fragment present in the same molecule. The porphyrin ligands for the platinum complexes were synthesized starting from hematoporphyrin and deuteroporphyrin. The platinum complexes are of the (diamine)PtCl2, (diamine)Pt(phthalato), (NH3)(2)Pt(dicarboxylato) and (diamine)Pt(dicarboxylato) type. Their antitumor activity was tested with the MDA-MB-231 mammary carcinoma cell line with and without irradiation. (C) 2003 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHOTODYNAMIC TUMOR-THERAPY; PHOTOTOXIC ANTITUMOR AGENTS; PHOTOCHEMOTHERAPEUTIC AGENTS; SULFONATED PHTHALOCYANINE; SELECTIVE BIODISTRIBUTION; MOLECULAR PROBES; LIVING CELLS; IN-VITRO; COMPLEXES; LIGANDS; porphyrin platinum conjugates; photodynamic effect; cytostatic effect; antitumor activity; tumor selectivity |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Anorganische Chemie > Alumni or Retired Professors > Prof. Dr. Henri Brunner |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Jul 2021 08:16 |
| Last Modified: | 21 Jul 2021 08:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37739 |
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