Garcia-Tsao, Guadalupe and Wiest, Reiner (2004) Gut microflora in the pathogenesis of the complications of cirrhosis. BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 18 (2). pp. 353-372. ISSN 1521-6918, 1532-1916
Full text not available from this repository. (Request a copy)Abstract
The gut flora plays an important role in the pathogenesis of the complications of cirrhosis. Cirrhotic patients are prone to develop bacterial infections, mainly the 'spontaneous' infection of ascites or spontaneous bacterial peritonitis. Other complications of cirrhosis, such as variceal haemorrhage and ascites, occur mostly or solely as a consequence of portal hypertension. Portal pressure increases initially as a consequence of an increased intrahepatic resistance but, once collaterals; have formed, high portal pressure is maintained by an increased splanchnic blood inflow secondary to vasodilatation. Splanchnic vasodilatation is the initiating event in the hyperdynamic circulatory state that aggravates the complications of cirrhosis. The gut flora plays a role in both the development of infections and in the hyperdynamic circulatory state of cirrhosis and, although less prominently, it also plays a role in the pathogenesis of hepatic encephalopathy. This chapter presents evidence regarding gut flora and its modification in the pathogenesis and management of these complications of cirrhosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SPONTANEOUS BACTERIAL PERITONITIS; TUMOR-NECROSIS-FACTOR; PORTAL-SYSTEMIC ENCEPHALOPATHY; SELECTIVE INTESTINAL DECONTAMINATION; BENZODIAZEPINE-LIKE COMPOUNDS; CYTOKINE-GENERATING ORGAN; GAMMA-AMINOBUTYRIC-ACID; MESENTERIC LYMPH-NODES; SMALL-BOWEL MOTILITY; HEPATIC-ENCEPHALOPATHY; cirrhosis; gut flora; spontaneous bacterial peritonitis; hyperdynamic circulation; hepatic encephalopathy; bacterial translocation; intestinal bacterial overgrowth; intestinal permeability |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 03 Aug 2021 12:35 |
| Last Modified: | 03 Aug 2021 12:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37763 |
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