Schmitz, Gerd and Heimerl, Susanne and Langmann, Thomas (2004) Zinc finger protein ZNF202 structure and function in transcriptional control of HDL metabolism. CURRENT OPINION IN LIPIDOLOGY, 15 (2). pp. 199-208. ISSN 0957-9672
Full text not available from this repository. (Request a copy)Abstract
Purpose of review The zinc finger protein ZNF202 is a transcriptional repressor controlling promoter elements predominantly found in genes involved in lipid metabolism and energy homeostasis. Here we summarize the structure, regulation and modulation of ZNF202 function by protein interactions. Recent findings We review recent data and discuss the importance of the steadily growing list of ZNF202 target genes, defining a central role for ZNF202 as a key transcriptional regulator in metabolic disorders. Furthermore, we provide an interlink between transcriptional repression by ZNF202 and enhancement of gene activation via nuclear receptor coactivation by SCAN domain protein 1. Summary The novel findings suggest that ZNF202 together with other SCAN domain proteins orchestrates a complex transcriptional regulatory network, which justifies a further exploration of its potential as a therapeutic target in lipid disorders such as atherosclerosis and associated metabolic syndromes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOTHELIAL GROWTH-FACTOR; PHOSPHOLIPID TRANSFER PROTEIN; BETA(3)-ADRENERGIC RECEPTOR GENE; LYMPHOCYTE-ACTIVATION GENE-3; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; DENSITY-LIPOPROTEIN CONVERSION; TISSUE-SPECIFIC EXPRESSION; TYROSINE-HYDROXYLASE GENE; APOLIPOPROTEIN-E GENE; ZNF202; SCAN; SDP1; PPARs; HDL |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jul 2021 05:07 |
| Last Modified: | 26 Jul 2021 05:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/37773 |
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