Schweikl, Helmut and Schmalz, G. and Weinmann, W. (2004) The induction of gene mutations and micronuclei by oxiranes and siloranes in mammalian cells in vitro. JOURNAL OF DENTAL RESEARCH, 83 (1). pp. 17-21. ISSN 0022-0345
Full text not available from this repository.Abstract
Oxiranes and siloranes are candidate molecules for the development of composite materials with low shrinkage. Since some of these molecules are highly reactive, they could lead to adverse biological effects from underlying genetic mechanisms. Therefore, we analyzed the formation of micronuclei (chromosomal aberrations) and the induction of gene mutations (HPRT assay) in mammalian cells. The numbers of micronuclei induced by the oxirane di(cyclohexene-epoxidemethyl)ether (Eth-Ep) at low concentrations (10 muM) were about five-fold higher than controls. The related compound epoxy cyclohexyl methyl-epoxy cyclo-hexane carboxylate (Est-Ep) was less effective. The activity of diglycidylether of bisphenol A (BADGE) was even lower but similar to the most reactive silorane, di-3,4-epoxy cyclohexylmethyldimethyl-silane (DiMe-Sil). No induction of micronuclei was detected in the presence of a rat liver homogenate (S9). Est-Ep and Eth-Ep also induced gene mutations. Our analyses indicated low mutagenic potentials of siloranes; however, some oxiranes induced strong effects at two genetic endpoints.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UNPOLYMERIZED RESIN MONOMERS; SALMONELLA-TYPHIMURIUM; MUTAGENIC ACTIVITY; DENTAL COMPOSITES; FILLING MATERIALS; V79 CELLS; BIOCOMPATIBILITY; 1,2,3,4-DIEPOXYBUTANE; GENOTOXICITY; COMPONENTS; oxirane; silorane; mutagenicity; V79/HPRT; micronucleus test |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie > Prof. Dr. rer. nat. Helmut Schweikl |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Aug 2021 09:05 |
| Last Modified: | 04 Aug 2021 09:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38186 |
Actions (login required)
 |
View Item |
