Lerch, Klaus and Kalteis, T. and Schubert, T. and Lehn, N. and Grifka, Joachim (2003) Prosthetic joint infections with osteomyelitis due to Candida albicans. MYCOSES, 46 (11-12). pp. 462-466. ISSN 0933-7407
Full text not available from this repository.Abstract
We report the case of a 78-year-old woman who suffered from a severe soft tissue and bone infection of her left knee 3 years after a total knee-joint replacement without loosening of her endoprosthesis. Cultures from joint aspiration and tissue specimen identified Staphylococcus aureus and Candida albicans. Direct microscopic examination of vital spongy bone and fibrous tissue revealed microabscesses and seeds of yeasts inside the fatty marrow and interface. After removal of the prosthesis several soft tissue and bone specimens were taken during planned re-operations. The histological examination showed no morphological changing, no reduction or extinction of the yeast cells under fluconazole therapy with a dosage of 6 mg kg(-1) body weight (400 mg daily). Curing of the fungal infection with eradication of the yeasts in the bony specimens was achieved with higher doses of 12 mg kg(-1) body weight (800 mg day(-1)) over a 2 month regimen in combination with repeated surgical debridements.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-CEMENT; FLUCONAZOLE; ETEST; ARTHROPLASTY; Candida; arthritis; osteomyelitis; endoprosthesis; fluconazole |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Orthopädie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Aug 2021 09:01 |
| Last Modified: | 25 Aug 2021 09:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38375 |
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