Schlachetzki, Felix and Pardridge, William M. (2003) P-glycoprotein and caveolin-1 alpha in endothelium and astrocytes of primate brain. NEUROREPORT, 14 (16). pp. 2041-2046. ISSN 0959-4965, 1473-558X
Full text not available from this repository. (Request a copy)Abstract
P-glycoprotein (P-gp) and caveolin-1alpha are both involved in membrane transport, and studies in rodent brain show that these proteins are specifically localized at the microvascular endothelium, which forms the blood-brain barrier (BBB). In humans, P-gp is also expressed in astrocytes, especially in pathological tissue. The present study examines the cellular expression of P-gp and caveolin-1alpha in fresh-frozen brain from healthy rhesus monkey using confocal microscopy and polyclonal antibodies against either P-gp or caveolin-1alpha co-labeled for astrocytes or microvascular endothelium. P-gp and caveolin-1alpha are expressed in both astrocytes and endothelium of healthy primate brain. These findings suggest that P-gp and caveolin-1alpha share abroad spectrum of cellular expression and may play a role in drug transport within the brain in addition to the BBB.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTIDRUG-RESISTANCE; GLUCOSE-TRANSPORTER; MONOCLONAL-ANTIBODY; EXPRESSION; CELLS; BARRIER; MICROVESSELS; CAPILLARIES; PROTEINS; RAT; astrocytes; blood-brain barrier; caveolin-1 alpha drug transport; endothelium; P-glycoprotein |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Aug 2021 09:00 |
| Last Modified: | 27 Aug 2021 09:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38414 |
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