Johann, Monika and Bobbe, Gabriela and Putzhammer, Albert and Wodarz, Norbert (2003) Comorbidity of alcohol dependence with attention-deficit hyperactivity disorder: Differences in phenotype with increased severity of the substance disorder, but not in genotype (serotonin transporter and 5-hydroxytryptamine-2c receptor). ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 27 (10). pp. 1527-1534. ISSN 0145-6008
Full text not available from this repository. (Request a copy)Abstract
Background: Nearly 50% of subjects with continuing symptoms of attention-deficit hyperactivity disorder (ADHD) in adulthood have been reported to show a comorbid substance use disorder. Both ADHD and alcohol dependence have a high genetic load and might even share overlapping sources of genetic liability. Recently, the functional relevant polymorphism within the promoter region of the serotonin transporter gene (5-HTT) and the 5-hydroxytryptamine-2c (5-HT2c) receptor Cys23Ser have been proposed as candidate genes for both entities. Methods: We investigated phenotype and 5-HTT/5-HT2c genotype characteristics in 314 alcoholics of German descent. Results: There was no significant difference in 5-HTT genotype or 5-HT2c allele distribution between alcoholics and matched controls. Sixty-seven alcoholics fulfilled DSM-IV criteria of ADHD with ongoing symptoms in adulthood and had a Wender Utah Rating Scale score greater than 90. Thirty had ADHD plus antisocial personality disorder. The subgroup of alcoholics with ADHD (ADHD(+)) showed a significantly higher daily and record ethanol intake per month, an earlier age at onset of alcohol dependence, and a higher frequency of suicidal ideation, court proceedings, and antisocial personality disorder. In our sample, more than 50% of type 2 alcoholics according to Cloninger consist of the ADHD(+) and/or antisocial personality disorder-positive subjects. There were no differences in 5-HTT genotype or 5-HT2c allele distribution between the ADHD(+) subgroups and alcoholics without comorbidity and matched controls, respectively. Conclusions: Comorbidity of alcoholism and ADHD forms a distinct phenotype that shows an increased severity of the substance disorder. This phenotype contributes substantially to the so-called type 2 alcoholics according to Cloninger. In our sample, the functional relevant 5-HTT promoter and the 5-HT2c receptor Cys23Ser polymorphism do not contribute to the supposed common genetic predisposition of ADHD and alcohol dependence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 5-HYDROXYINDOLEACETIC ACID CONCENTRATIONS; DIMINISHED SOCIAL COMPETENCE; PROMOTER REGION POLYMORPHISM; GENE REGULATORY REGION; NONHUMAN PRIMATE MODEL; UTAH RATING-SCALE; DSM-III-R; DEFICIT/HYPERACTIVITY DISORDER; 5-HT2C RECEPTOR; PSYCHIATRIC COMORBIDITY; serotonin transporter polymorphism; 5-HT2c Cys23Ser polymorphism; alcohol dependence; attention-deficit hyperactivity disorder; Cloninger type 1 and 2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Aug 2021 08:05 |
| Last Modified: | 30 Aug 2021 08:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38528 |
Actions (login required)
 |
View Item |
