Meems, Laura M. G. and Mahmud, Hasan and Buikema, Hendrik and Tost, Jorg and Michel, Sven and Takens, Janny and Verkaik-Schakel, Rikst N. and Vreeswijk-Baudoin, Inge and Mateo-Leach, Irene V. and van der Harst, Pim and Plosch, Torsten and de Boer, Rudolf A. (2016) Parental vitamin D deficiency during pregnancy is associated with increased blood pressure in offspring via Panx1 hypermethylation. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 311 (6). H1459-H1469. ISSN 0363-6135, 1522-1539
Full text not available from this repository. (Request a copy)Abstract
Vitamin D deficiency is one of the most common nutritional deficiencies worldwide. Maternal vitamin D deficiency is associated with increased susceptibility to hypertension in offspring, but the reasons for this remain unknown. The aim of this study was to determine if parental vitamin D deficiency leads to altered DNA methylation in offspring that may relate to hypertension. Male and female Sprague-Dawley rats were fed a standard or vitamin D-depleted diet. After 10 wk, nonsibling rats were mated. The conceived pups received standard chow. We observed an increased systolic and diastolic blood pressure in the offspring from depleted parents (F1-depl). Genome-wide methylation analyses in offspring identified hypermethylation of the promoter region of the Pannexin-1 (Panx1) gene in F1-depl rats. Panx1 encodes a hemichannel known to be involved in endothelial-dependent relaxation, and we demonstrated that in F1-depl rats the increase in blood pressure was associated with impaired endothelial relaxation of the large vessels, suggesting an underlying biological mechanism of increased blood pressure in children from parents with vitamin deficiency. Parental vitamin D deficiency is associated with epigenetic changes and increased blood pressure levels in offspring.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLASMA-RENIN ACTIVITY; DNA-METHYLATION; DUTCH FAMINE; ENDOTHELIAL FUNCTION; RENAL-INSUFFICIENCY; CARDIOVASCULAR RISK; HEART-FAILURE; PANNEXIN 1; HYPERTENSION; ABNORMALITIES; blood pressure; epigenetics; vitamin D; endothelial dysfunction; Pannexin-1 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Apr 2019 08:19 |
| Last Modified: | 10 Apr 2019 08:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3856 |
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