Burchardt, E. R. and Hein, R. and Bosserhoff, Anja K. (2003) Laminin, hyaluronan, tenascin-C and type VI collagen levels in sera from patients with malignant melanoma. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 28 (5). pp. 515-520. ISSN 0307-6938, 1365-2230
Full text not available from this repository. (Request a copy)Abstract
In this study, hyaluronan, laminin-1, tenascin-C and type VI collagen were measured in the sera of patients with stage I/II and stage IV melanoma. A significant increase in the serum levels of all four extracellular matrix proteins was found in patients with stage IV melanoma compared to healthy donors. Type VI collagen and hyaluronan serum levels were also significantly increased in stage I/II melanoma. Increased expression of the four matrix proteins was also demonstrated in melanoma cell lines using reverse transcriptase - polmerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay ( ELISA). We suggest that tenascin-C, hyaluronan, laminin-1 and type VI collagen are involved in melanoma development and extracellular matrix remodelling during melanoma progression. This finding will be of interest in the development of serum markers for progression of malignant melanoma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENZYME-IMMUNOASSAY; CUTANEOUS MELANOMA; BREAST-CANCER; IN-VITRO; EXPRESSION; TUMOR; CELLS; PROGNOSIS; CARCINOMA; INVASION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Sep 2021 12:23 |
| Last Modified: | 01 Sep 2021 12:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38646 |
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