Brunner, Henri and Schellerer, K.-M. (2003) New porphyrin platinum conjugates for the cytostatic and photodynamic tumor therapy. INORGANICA CHIMICA ACTA, 350. pp. 39-48. ISSN 0020-1693
Full text not available from this repository.Abstract
The combination of a porphyrin system and a platinum fragment in the same molecule should not only result in the additivity of the photodynamic activity of the porphyrin and the cytostatic activity of the platinum, but also in the enrichment of the porphyrin platinum conjugate in tumors, which platinum compounds alone do not show. New porphyrin platinum conjugates were obtained from the platinum complexes of a series of 1,2-diamines and hematoporphyrin or 13,17-bis(2-carboxyethyl)-3,8-bis [1-(ethyleneglycolmonoethylether)oxvethyl]-2,7,12,18-tetramethylporphin. The 1,2-diamines were synthesized starting from the corresponding stilbenes via 1,2-diazides. The new platinum porphyrin conjugates showed promising antitumor activity in tests with the mammary carcinoma cell line MDA-MB-231. (C) 2003 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHOTOTOXIC ANTITUMOR AGENTS; COMPLEXES; LIGANDS; LIPOSOMES; MECHANISM; porphyrin platinum conjugates; cytostatic tumor therapy; photodynamic tumor therapy; MDA-MB-231 cell line |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Anorganische Chemie > Alumni or Retired Professors > Prof. Dr. Henri Brunner |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2021 13:22 |
| Last Modified: | 10 Aug 2021 13:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/38830 |
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