Three-dimensional ultrasonic gait analysis in schizophrenic patients - Differences between conventional neuroleptic treatment and treatment with olanzapine

Putzhammer, Albert and Heindl, Bernhard and Mueller, Juergen and Broll, Karin and Pfeiff, Liane and Perfahl, Maria and Hess, Linda and Koch, Horst (2003) Three-dimensional ultrasonic gait analysis in schizophrenic patients - Differences between conventional neuroleptic treatment and treatment with olanzapine. PSYCHIATRISCHE PRAXIS, 30. S110-S114. ISSN 0303-4259

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Abstract

Schizophrenic disorders as well as neuroleptic treatment can affect locomotion. The study assessed the influence of neuroleptic treatment on human gait via ultrasonic topometric gait analysis. In a control sample the test system proved high test-retest-reliability. Spatial and temporal gait parameters were assessed in schizophrenic patients without neuroleptic treatment (n = 12) and under treatment with conventional neuroleptics (n = 14) and re-assessed after treatment change to the atypical neuroleptic olanzapine in a repeated measures design. After switch from conventional neuroleptics to olanzapine patients showed an increase of gait velocity (p less than or equal to 0.01) and step length (p less than or equal to 0.01) whereas the cadence remained stable. Significant differences between the untreated state and treatment with olanzapine were not detectable. We conclude that bipedal gait is affected by conventional neuroleptic treatment. The degree of impairment can be objectively measured by testing spatio-temporal and kinematic gait parameters via three-dimensional ultrasonic gait analysis.

Item Type: Article
Uncontrolled Keywords: LUMBAR SPINE KINEMATICS; PARKINSONS-DISEASE; HALOPERIDOL; MOVEMENTS; WALKING; PLACEBO; SIGNS;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Depositing User: Dr. Gernot Deinzer
Date Deposited: 14 Sep 2021 11:52
Last Modified: 14 Sep 2021 11:52
URI: https://pred.uni-regensburg.de/id/eprint/39091

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