Hartmann, Arndt and Dietmaier, Wolfgang and Hofstaedter, Ferdinand and Burgart, Lawrence J. and Cheville, John C. and Blaszyk, Hagen (2003) Urothelial carcinoma of the upper urinary tract: Inverted growth pattern is predictive of microsatellite instability. HUMAN PATHOLOGY, 34 (3). pp. 222-227. ISSN 0046-8177, 1532-8392
Full text not available from this repository.Abstract
Urothelial carcinoma of the renal pelvis and ureter may develop as a manifestation of hereditary nonpolyposis colorectal cancer syndrome (HNPCC), a disorder characterized by mutation or inactivation of a number of DNA mismatch repair genes and detectable as microsatellite instability (MSI). Some urothelial carcinomas display areas of endophytic, or inverted, growth. In this study, urothelial cancers of the upper urinary tract (n = 132) from patients treated at 2 tertiary care centers were studied to identify an association between growth pattern and MSI. Thirty-five neoplasms were microsatellite unstable (26.5%), and MSI was more frequent in papillary lesions than in sessile urothelial cancers (P = .033). The amount of inverted growth was estimated as a percentage of the total tumor. The interobserver and intraobserver concordance in recognizing inverted growth was good, and 65.7% of microsatellite-unstable tumors exhibited at least 20% of an inverted growth component, compared with only 17.5% of microsatellite-stable tumors (P < .0001). In this series, inverted growth predicted MSI with a sensitivity and specificity of .82. Inverted growth in urothelial carcinomas of the upper urinary tract may serve as a marker lesion for MSI and may help identify patients who should be offered testing for HNPCC. Copyright 2003 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONPOLYPOSIS COLORECTAL-CANCER; HEREDITARY; PAPILLOMA; BLADDER; TUMORS; hereditary nonpolyposis colorectal cancer syndrome; microsatellite instability; inverted urothelial carcinoma; upper urinary tract |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Sep 2021 12:39 |
| Last Modified: | 15 Sep 2021 12:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39233 |
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