Eichhammer, Peter and Langguth, Berthold and Wiegand, Rainer and Kharraz, Alexander and Frick, Ulrich and Hajak, Goeran (2003) Allelic variation in the serotonin transporter promoter affects neuromodulatory effects of a selective serotonin transporter reuptake inhibitor (SSRI). PSYCHOPHARMACOLOGY, 166 (3). pp. 294-297. ISSN 0033-3158
Full text not available from this repository. (Request a copy)Abstract
Rationale: Antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs) has been shown to depend on functional polymorphisms within the promoter region of the serotonin transporter gene (5-HTTLPR). This gene gives rise to a biallelic polymorphism designated long (1) and short (s). Homozygosity for the long variant (11-genotype) is associated with a two times more efficient 5-HT uptake compared to the s/l- or s/sgenotype. Paired pulse transcranial magnetic stimulation is a feasible tool in detecting changes of motor cortex excitability induced by SSRIs. Objective: Our study aimed to measure neuromodulatory effects of SSRIs on cortical excitability in healthy volunteers characterized by distinct genotypes of the 5-HTTLPR. Methods: Cortical excitability was determined in eight genetically defined subjects pre- and post-ingestion of 60 mg citalopram. Results: Subjects with the 11-genotype of the 5-HTTLPR showed a significant enhancement of a particular component of motor cortex excitability (intracortical inhibition) as compared to volunteers without the 11-genotype. Conclusion: Distinct neuromodulatory effects after intake of citalopram based on allelic variations of the 5-HTTLPR may explain variable response of patients treated with SSRIs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; MOTOR CORTEX EXCITABILITY; PREFRONTAL CORTEX; BRAIN; CITALOPRAM; GENE; POLYMORPHISM; VARIABILITY; EXPRESSION; DEPRESSION; paired pulse transcranial magnetic stimulation; serotonin gene transporter polymorphism; serotonin transporter reuptake inhibitor; motor cortex excitability |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Sep 2021 06:14 |
| Last Modified: | 20 Sep 2021 06:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39258 |
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