Holmer, Stephan R. and Hengstenberg, Christian and Kraft, Hans Georg and Mayer, Bjoern and Poell, Melanie and Kuerzinger, Susanne and Fischer, Marcus and Loewel, Hannelore and Klein, Gernot and Riegger, Guenter A. J. and Schunkert, Heribert (2003) Association of polymorphisms of the apolipoprotein(a) gene with lipoprotein(a) levels and myocardial infarction. CIRCULATION, 107 (5). pp. 696-701. ISSN 0009-7322
Full text not available from this repository. (Request a copy)Abstract
Background-Serum lipoprotein(a) [Lp(a)] concentration is largely determined by variability at the apolipoprotein(a) gene locus. Most prominent effects relate to polymorphisms in the promoter (a pentanucleotide [PN] repeat) and coding regions (a kringle IV [K4] repeat), the latter of which also affects Lp(a) particle size. The impact of these polymorphisms on cardiovascular risk is poorly understood. Methods and Results-We studied both polymorphisms and Lp(a) levels in 834 registry-based myocardial infarction (MI) patients (38% women) and 1548 population-based controls. Lp(a) concentrations were inversely related with the numbers of K4 and PN repeats. However, the effect of the PN polymorphism was restricted to subjects producing small Lp(a) particles (less than or equal to8 PN 66.1 mg/dL versus >8 PN 8.7 mg/dL; P<0.0001). The odds to present with MI were elevated in individuals producing small Lp(a) particles (<= 22 K4 repeats; OR 1.47 for men and 1.69 for women; P<0.002) and in women with less than or equal to8 PN repeats (OR 1.46, P=0.009). Interestingly, in women, the frequent haplotype with less than or equal to8 PN and less than or equal to22 K4 repeats, which is related to high levels of small Lp(a) particles, resulted in an elevated OR for MI (1.79; P=0.01) independently of Lp( a) serum concentration. Conclusions-The K4 and PN repeat polymorphisms largely explain the high variability of serum Lp(a) levels. A haplotype with less than or equal to8 PN and less than or equal to22 K4 repeats is characterized by high concentrations of small Lp(a) particles. Our observation that this haplotype was associated with MI independently of Lp(a) serum levels may suggest that Lp(a) particle size in addition to its concentration may modulate MI risk in women.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-HEART-DISEASE; PENTANUCLEOTIDE REPEAT POLYMORPHISM; RISK-FACTORS; APO(A) GENE; ELEVATED LIPOPROTEIN(A); SEQUENCE POLYMORPHISMS; PLASMA LIPOPROTEIN(A); LP(A) CONCENTRATION; SIZE POLYMORPHISM; WOMEN; apolipoproteins; polymorphism; myocardial infarction; women; population |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Sep 2021 06:52 |
| Last Modified: | 20 Sep 2021 06:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39279 |
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