Honrubia, F. M. and Larsson, L. I. and Spiegel, D. (2002) A comparison of the effects on intraocular pressure of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5% in patients with open-angle glaucoma. ACTA OPHTHALMOLOGICA SCANDINAVICA, 80 (6). pp. 635-641. ISSN 1395-3907
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Purpose: To compare the effects on intraocular pressure (IOP) of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5%. Methods: Overall, 226 patients whose IOP was insufficiently controlled by timolol alone were randomized to receive either latanoprost once daily or the fixed combination of dorzolamide plus timolol twice daily. Intraocular pressure was measured at 10 : 00 am and 5 : 00 pm at baseline and after 3 months of treatment. Results: Mean IOP was reduced from baseline in both groups (p < 0.001), with a mean +/- SEM reduction of - 4.3 +/- 0.3 mmHg (19%) for the latanoprost treatment group and - 4.0 +/- 0.3 mmHg (17%) for the dorzolamide plus timolol treatment group. The two therapies were similarly effective in lowering IOP levels (mean difference in reduction: - 0.4 +/- 0.4; 95% confidence interval: - 1.1, 0.4). Conclusions: Monotherapy with latanoprost once daily was as effective in reducing mean IOP as the fixed combination of dorzolamide plus timolol twice daily in patients with IOP insufficiently controlled by timolol alone.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OCULAR HYPERTENSION; RANDOMIZED TRIAL; HUMAN EYES; MONOTHERAPY; ANALOG; MULTICENTER; EFFICACY; BRINZOLAMIDE; DYNAMICS; 6-MONTH; intraocular pressure; open-angle glaucoma; treatment; latanoprost; dorzolamide; timolol |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Mar 2022 06:46 |
| Last Modified: | 21 Mar 2022 06:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39579 |
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