Schumacher, Karl and Strehl, Raimund and de Vries, Uwe and Groene, Hermann Josef and Minuth, Will W. (2002) SBA-positive fibers between the CD ampulla, mesenchyme, and renal capsule. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 13 (10). pp. 2446-2453. ISSN 1046-6673
Full text not available from this repository. (Request a copy)Abstract
During kidney development, the CD shows two peculiarities. First, the tip of the CD ampulla is always found at a specific distance from the organ capsule. Second, the CD growth occurs as a perfectly straight elongation. It is unknown whether the CD-specific growth is dependent on hormonal action or on structural elements. Histochemical experiments on neonatal rabbit kidney yielded new insight into the interface of the CD ampulla and the surrounding nephrogenic mesenchyme. Incubation of tissue sections with soybean lectin (SBA) showed the existence of fibers extending in a radial course from the ampullar tip through the mesenchyme toward the organ capsule. SBA labeling did not colocalize with collagen type I, III, IV, V, and VI, laminin, fibronectin, and tenascin. It is assumed that while the kidney increases in volume the structural fixation of the ampullar tip by the SBA-positive fibers causes CD ampullae to maintain a constant distance from the organ capsule. The connection would explain the linear extension of the CD in relation to the organ capsule. In addition, the presented data suggest that the SBA-positive fibers between ampullar tip and organ capsule create a structural microcompartmentation of the nephrogenic zone.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN KIDNEY MALFORMATIONS; CELL-SURFACE PROTEOGLYCAN; URETERAL BUD CELLS; BRANCHING MORPHOGENESIS; MOUSE KIDNEY; INTEGRIN ALPHA-8-BETA-1; METANEPHRIC DEVELOPMENT; TRANSCRIPTION FACTOR; GROWTH-FACTORS; IN-VITRO; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie > Prof. Dr. Will Minuth |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Oct 2021 06:15 |
| Last Modified: | 05 Oct 2021 06:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39842 |
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