Christgau, Michael and Bader, N. and Felden, A. and Gradl, J. and Wenzel, A. and Schmalz, G. (2002) Guided tissue regeneration in intrabony defects using an experimental bioresorbable polydioxanon (PIDS) membrane - A 24-month split-mouth study. JOURNAL OF CLINICAL PERIODONTOLOGY, 29 (8). pp. 710-723. ISSN 0303-6979, 1600-051X
Full text not available from this repository. (Request a copy)Abstract
Aim: The comparison of the clinical, radiographic, and microbiological healing results in deep intrabony defects following GTR therapy with two different bioresorbable membranes in a prospective split-mouth design. Material and methods: 31 pairs of contralateral intrabony defects were randomly treated with either an experimental Polydioxanon (PDS) membrane or a Polylactic acid (PLA) matrix barrier. After 6, 12 and 24 months, healing results were assessed using clinical examinations (REC, PPD, CAL, vertical relative attachment gain V-rAG), quantitative digital subtraction radiography (amount and area of bone density changes), and microbiological analysis. Results: Postoperative membrane exposures occurred in 14 PDS and 2 PLA treated sites. 6, 12 and 24 months p.o., both membranes provided a significant gain in CAL [median values: 6 months (PDS vs. PLA: 3.0 vs. 3.0 mm); 12 and 24 months (PDS vs. PLA: 4.0 vs. 4.0 mm)], which corresponded to a V-rAG of 57.1% (PDS) vs. 62.5% (PLA) after 24 months. PDS and PLA treated sites revealed significant bone density gain 6, 12 and 24 months after surgery. 38.8% (PDS) vs. 41.8% (PLA) of the initial defect areas showed bone density gain. While the gain in bone density was significantly greater in PDS than in PLA sites, neither CAL gain nor the area of bone density changes revealed significant differences. Microbiological culture revealed similar bacterial loads in PDS and PLA sites during the first 12 months. Conclusion: This 24-month study indicates that the PDS and PLA membranes can provide similar favorable regeneration results in deep intrabony periodontal defects, although considerably more postoperative membrane exposures have to be expected in PDS treated sites.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTROLLED CLINICAL-TRIAL; HUMAN INFRABONY DEFECTS; II FURCATION DEFECTS; LONG-TERM STABILITY; PERIODONTAL REGENERATION; BARRIER MEMBRANES; BACTERIAL-COLONIZATION; BIODEGRADABLE BARRIERS; BIOABSORBABLE BARRIERS; ATTACHMENT FORMATION; guided tissue regeneration; intrabony defects; microbiology; periodontal disease surgery; polydioxanon; polylactic acid; subtraction radiography |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Oct 2021 06:33 |
| Last Modified: | 12 Oct 2021 06:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40041 |
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