Goepel, Wolfgang and Kattner, Evelyn and Seidenberg, Juergen and Kohlmann, Thomas and Segerer, Hugo and Moeller, Jens (2002) The effect of the Val34Leu polymorphism in the factor XIII gene in infants with a birth weight below 1500 g. JOURNAL OF PEDIATRICS, 140 (6). pp. 688-692. ISSN 0022-3476, 1097-6833
Full text not available from this repository.Abstract
Objectives: The 3-4Leu polymorphism of the factor XIII gene is associated with a low rate of brain infarction and a higher incidence of primary intracerebral hemorrhage in adults. We evaluated the effect of the polymorphism on the subsequent development of isolated intracranial hemorrhage and white matter disease in preterm infants with a birth weight <1500 g (verb, low birth weight [VLBW] infants). Study design: We studied 531 VLBW infants and 301 control infants born at term. The factor XIII 34Leu polymorphism was detected by polymerase chain reaction and restriction enzyme digestion. Results: Allele frequencies were not different from term and VLBW infants (Val/Val, 53.1% and.57.8%; Val/Leu, 38.8% and 37.6%; Leu/Leu, 8.0% and 4.5%, respectively). VLBW infants carrying the Leu/Val or Leu/Leu allele had a significant reduced risk of the development of white matter disease (3.6% vs 10.4% in infants without the polymorphism, P = .003). In a multivariate logistic regression analysis, only gestational age <28 weeks (odds ratio, 3.8; 95% confidence interval, 1.9-7.5; P < .001), and the factor XIII 34Leu al- lele (odds ratio, 0.3; 95% confidence interval, 0.1-0.7; P = .005) had significant prognostic value in predicting subsequent white matter disease. However, VLBW infants who carried the factor XIII 34Leu allele also had a moderately increased risk of the subsequent development of isolated intraventricular hemorrhage (14.3% vs 10.1% in infants without the mutation, P = .17). Conclusions: VLBW infants carrying the factor XIII 34Leu polymorphism had a decreased risk for white matter disorders.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COAGULATION-FACTOR-XIII; VENOUS THROMBOSIS; MYOCARDIAL-INFARCTION; COMMON POLYMORPHISM; A-SUBUNIT; ASSOCIATION; ACTIVATION; HEMORRHAGE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Oct 2021 13:54 |
| Last Modified: | 25 Oct 2021 13:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40209 |
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