Strehl, Raimund and Schumacher, Karl and de Vries, Uwe and Minuth, Will W. (2002) Proliferating cells versus differentiated cells in tissue engineering. TISSUE ENGINEERING, 8 (1). pp. 37-42. ISSN 1076-3279
Full text not available from this repository. (Request a copy)Abstract
The efficiency of cell or tissue cultures is usually judged by how quickly confluence is reached within a Petri dish or on a scaffold. Growth factors and fetal bovine serum are employed to drive cultured cells from one mitosis to the next as quickly as possible. The tissue specific interphase is extremely short under these conditions, so that the degree of differentiation desired in tissue engineering cannot be achieved. To reach the goal of functional differentiation in vitro mitosis and interphase must be separated experimentally and tailored to the specific requirements of the cell-type used. This could be achieved by a three step concept for tissue-engineering in vitro as we present here. The expansion phase is followed by a phase in which tissue differentiation is initiated. The final phase serves to express and maintain histotypical differentiation of the generated tissue.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERFUSION CULTURE; GROWTH ARREST; COLLAGEN; OXYGEN; SERUM; FIBROBLASTS; EXPRESSION; CARTILAGE; DELIVERY; STRESS; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie > Prof. Dr. Will Minuth |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2021 08:08 |
| Last Modified: | 15 Nov 2021 08:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40660 |
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