Lee, Bong-Seop and Holler, Eggehard (2000) beta-poly(L-malate) production by non-growing microplasmodia of Physarum polycephalum - Effects of metabolic intermediates and inhibitors. FEMS MICROBIOLOGY LETTERS, 193 (1). pp. 69-74. ISSN 0378-1097
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The production of beta -poly(L-malate) (PMLA) by non-growing microplasmodia of Physarum polycephalum was investigated. Growth was minimal in culture medium devoid of nitrogen source, but PMLA production occurred at a substantial rate. The addition of metabolic intermediates, malate, fumarate, succinate, and oxaloacetate, and the omission of hematin showed considerable growth inhibition in the presence of the nitrogen source, while PMLA production per unit biomass increased significantly. The results indicated that PMLA production was dissociated from biomass production under these conditions. The stimulating effect of carbonate on PMLA production was independent on growth. Cultivation in the absence of the nitrogen source and hematin or in the presence of the metabolites may be a useful technique for efficient PMLA production at a minimum of biomass production. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLY-L-MALATE; AUREOBASIDIUM-PULLULANS; ACID); POLYMERASE; INVITRO; beta-poly(L-malate); non-growing cell; metabolic intermediate; inhibitor; Physarum polycephalum |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Alumni or Retired > Prof. Dr. Eggehard Holler |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Mar 2022 07:57 |
| Last Modified: | 14 Mar 2022 07:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42000 |
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