Schmalz, Gottfried and Hoffmann, Matthias and Weis, Kurt and Schweikl, Helmut (2000) Influence of albumin and collagen on the cell mortality evoked by zinc oxide-eugenol in vitro. JOURNAL OF ENDODONTICS, 26 (5). pp. 284-287. ISSN 0099-2399
Full text not available from this repository. (Request a copy)Abstract
Zinc oxide-eugenol (ZOE) is cytotoxic in vitro but does not cause pulp damage. Various dentin proteins may play a protective role in vivo, We investigated the influence of bovine serum albumin (BSA) and collagen on ZOE cytotoxicity in the Millipore filter test and a dentin barrier test. Agar or agarose with 1% or 5% BSA or calf collagen (1% and 2%) were introduced between L-929 fibroblasts and test specimens, ZOE was severely toxic in the absence of BSA, However BSA (1% and 3%) reduced cell damage to 50% and 35%, In contrast, collagen did not provide protection from ZOE cytotoxicity. When dentin was loaded with 3% BSA and the "pulpal" side of a dentin barrier test chamber was perfused with cell culture medium containing 3% BSA, cytotoxicity of ZOE was completely inhibited. Therefore we conclude that albumin may be one factor responsible for the absence of ZOE toxicity in pulp studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DENTIN BARRIER TEST; CYTO-TOXICITY; GLASS-IONOMER; INVITRO; CEMENTS; PULP; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie > Prof. Dr. rer. nat. Helmut Schweikl |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 May 2022 09:27 |
| Last Modified: | 10 May 2022 09:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42528 |
Actions (login required)
 |
View Item |
