Holler, Ernst and Roncarolo, M. G. and Hintermeier-Knabe, R. and Eissner, Guenther and Ertl, B. and Schulz, U. and Knabe, H. and Kolb, H. J. and Andreesen, Reinhard and Wilmanns, W. (2000) Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation. BONE MARROW TRANSPLANTATION, 25 (3). pp. 237-241. ISSN 0268-3369
Full text not available from this repository. (Request a copy)Abstract
IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine, To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 patients admitted for allogeneic BMT. High spontaneous IL-10 production by PBMNC at the time of admission and prior to any preparative treatment correlated with a subsequent low incidence of GVHD and transplant-related mortality (8%), as compared to patients with low or intermediate IL-10 production (50%, P < 0.01). Our data demonstrate the prognostic significance of increased IL-10 production in BMT patients and suggest a major role of IL-10 in maintaining immunobalance in the setting of allogeneic BMT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST DISEASE; NECROSIS-FACTOR-ALPHA; CELLS IN-VITRO; RADIATION-INDUCED ACTIVATION; SERUM LEVELS; INTERLEUKIN-10 PROTECTS; BACTERIAL-ENDOTOXIN; MURINE MODEL; COMPLICATIONS; RELEASE; bone marrow transplantation; IL-10; GVHD; TNF-alpha |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jun 2022 07:22 |
| Last Modified: | 07 Jun 2022 07:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42837 |
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