Maurer, Stefanie F. and Dieckmann, Sebastian and Lund, Jens and Fromme, Tobias and Hess, Anne Lundby and Colson, Cecilia and Kjolbaek, Louise and Astrup, Arne and Gillum, Matthew Paul and Larsen, Lesli Hingstrup and Liebisch, Gerhard and Amri, Ez-Zoubir and Klingenspor, Martin (2021) No Effect of Dietary Fish Oil Supplementation on the Recruitment of Brown and Brite Adipocytes in Mice or Humans under Thermoneutral Conditions. MOLECULAR NUTRITION & FOOD RESEARCH, 65 (2): 2000681. ISSN 1613-4125, 1613-4133
Full text not available from this repository. (Request a copy)Abstract
Scope Brown and brite adipocytes within the mammalian adipose organ provide non-shivering thermogenesis and thus, have an exceptional capacity to dissipate chemical energy as heat. Polyunsaturated fatty acids (PUFA) of the n3-series, abundant in fish oil, have been repeatedly demonstrated to enhance the recruitment of thermogenic capacity in these cells, consequently affecting body adiposity and glucose tolerance. These effects are scrutinized in mice housed in a thermoneutral environment and in a human dietary intervention trial. Methods and results Mice are housed in a thermoneutral environment eliminating the superimposing effect of mild cold-exposure on thermogenic adipocyte recruitment. Dietary fish oil supplementation in two different inbred mouse strains neither affects body mass trajectory nor enhances the recruitment of brown and brite adipocytes, both in the presence and absence of a beta 3-adrenoreceptor agonist imitating the effect of cold-exposure on adipocytes. In line with these findings, dietary fish oil supplementation of persons with overweight or obesity fails to recruit thermogenic adipocytes in subcutaneous adipose tissue. Conclusion Thus, the authors' data question the hypothesized potential of n3-PUFA as modulators of adipocyte-based thermogenesis and energy balance regulation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WHITE ADIPOSE-TISSUE; HIGH-THROUGHPUT QUANTIFICATION; TANDEM MASS-SPECTROMETRY; N-3 FATTY-ACIDS; MESSENGER-RNA LEVEL; UNCOUPLING PROTEIN-1; UP-REGULATION; OBESE MICE; MOUSE; UCP1; adipose tissue; fish oil; n3; n6; obesity; polyunsaturated fatty acids; thermogenesis; uncoupling protein 1 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 May 2021 14:38 |
| Last Modified: | 17 May 2021 14:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43114 |
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