Haferkamp, Sebastian and Drexler, Konstantin and Federlin, Marianne and Schlitt, Hans J. and Berneburg, Mark and Adamski, Jerzy and Gaumann, Andreas and Geissler, Edward K. and Ganapathy, Vadivel and Parkinson, E. Kenneth and Mycielska, Maria E. (2020) Extracellular Citrate Fuels Cancer Cell Metabolism and Growth. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 8: 602476. ISSN 2296-634X
Full text not available from this repository. (Request a copy)Abstract
Cancer cells need excess energy and essential nutrients/metabolites not only to divide and proliferate but also to migrate and invade distant organs for metastasis. Fatty acid and cholesterol synthesis, considered a hallmark of cancer for anabolism and membrane biogenesis, requires citrate. We review here potential pathways in which citrate is synthesized and/or supplied to cancer cells and the impact of extracellular citrate on cancer cell metabolism and growth. Cancer cells employ different mechanisms to support mitochondrial activity and citrate synthesis when some of the necessary substrates are missing in the extracellular space. We also discuss the different transport mechanisms available for the entry of extracellular citrate into cancer cells and how citrate as a master metabolite enhances ATP production and fuels anabolic pathways. The available literature suggests that cancer cells show an increased metabolic flexibility with which they tackle changing environmental conditions, a phenomenon crucial for cancer cell proliferation and metastasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOMIC ORGANIZATION; FUNCTIONAL FEATURES; TUMOR METABOLISM; MAMMALIAN-CELLS; PROSTATE-CANCER; DOWN-REGULATION; LIVER-CANCER; TRANSPORTER; FIBROBLASTS; IRON; cancer; metabolism; transporter; cancer associated fibroblast (CAF); senescent fibroblasts |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Apr 2021 13:22 |
| Last Modified: | 21 Apr 2021 13:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43175 |
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