Depner, Martin and Taft, Diana Hazard and Kirjavainen, Pirkka V. and Kalanetra, Karen M. and Karvonen, Anne M. and Peschel, Stefanie and Schmausser-Hechfellner, Elisabeth and Roduit, Caroline and Frei, Remo and Lauener, Roger and Divaret-Chauveau, Amandine and Dalphin, Jean-Charles and Riedler, Josef and Roponen, Marjut and Kabesch, Michael and Renz, Harald and Pekkanen, Juha and Farquharson, Freda M. and Louis, Petra and Mills, David A. and von Mutius, Erika and Ege, Markus J. (2020) Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. NATURE MEDICINE, 26 (11). 1766-+. ISSN 1078-8956, 1546-170X
Full text not available from this repository. (Request a copy)Abstract
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural Environments (PASTURE) birth cohort, we modeled maturation using 16S rRNA sequence data of the human gut microbiome in infants from 2 to 12 months of age. The estimated microbiome age (EMA) in 12-month-old infants was associated with previous farm exposure (beta = 0.27 (0.12-0.43), P = 0.001, n = 618) and reduced risk of asthma at school age (odds ratio (OR) = 0.72 (0.56-0.93), P = 0.011). EMA mediated the protective farm effect by 19%. In a nested case-control sample (n = 138), we found inverse associations of asthma with the measured level of fecal butyrate (OR = 0.28 (0.09-0.91), P = 0.034), bacterial taxa that predict butyrate production (OR = 0.38 (0.17-0.84), P = 0.017) and the relative abundance of the gene encoding butyryl-coenzyme A (CoA):acetate-CoA-transferase, a major enzyme in butyrate metabolism (OR = 0.43 (0.19-0.97), P = 0.042). The gut microbiome may contribute to asthma protection through metabolites, supporting the concept of a gut-lung axis in humans. Growing up in the rich microbial environment of a farm strongly influences the maturation of the gut microbiome in the first year of life, which helps protect against the development of asthma in children.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATOPY; RISK; DIVERSITY; BACTERIA; SUSCEPTIBILITY; POLYMORPHISMS; COLONIZATION; ENVIRONMENTS; ASSOCIATION; VARIANTS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2021 10:11 |
| Last Modified: | 08 Mar 2021 10:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/43423 |
Actions (login required)
 |
View Item |
