Mao, Xiaojun and Auer, David L. and Buchalla, Wolfgang and Hiller, Karl-Anton and Maisch, Tim and Hellwig, Elmar and Al-Ahmad, Ali and Cieplik, Fabian (2020) Cetylpyridinium Chloride: Mechanism of Action, Antimicrobial Efficacy in Biofilms, and Potential Risks of Resistance. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 64 (8): e00576-20. ISSN 0066-4804, 1098-6596
Full text not available from this repository. (Request a copy)Abstract
Antimicrobial resistance is a serious issue for public health care all over the world. While resistance toward antibiotics has attracted strong interest among researchers and the general public over the last 2 decades, the directly related problem of resistance toward antiseptics and biocides has been somewhat left untended. In the field of dentistry, antiseptics are routinely used in professional care, but they are also included in lots of oral care products such as mouthwashes or dentifrices, which are easily available for consumers over-the-counter. Despite this fact, there is little awareness among the dental community about potential risks of the widespread, unreflected, and potentially even needless use of antiseptics in oral care. Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which was first described in 1939, is one of the most commonly used antiseptics in oral care products and included in a wide range of over-the-counter products such as mouthwashes and dentifrices. The aim of the present review is to summarize the current literature on CPC, particularly focusing on its mechanism of action, its antimicrobial efficacy toward biofilms, and on potential risks of resistance toward this antiseptic as well as underlying mechanisms. Furthermore, this work aims to raise awareness among the dental community about the risk of resistance toward antiseptics in general.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUATERNARY AMMONIUM-COMPOUNDS; STREPTOCOCCUS-MUTANS; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANCE; DISINFECTANT RESISTANCE; CHLORHEXIDINE DIACETATE; PSEUDOMONAS-STUTZERI; ACQUIRED-RESISTANCE; RAPID-DETERMINATION; BIOCIDE RESISTANCE; CPC; adaptation; antiseptic; biocide; cetylpyridinium chloride; oral; resistance |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie > Dr. rer. nat. Karl-Anton Hiller |
| Depositing User: | Petra Gürster |
| Date Deposited: | 15 Apr 2021 07:00 |
| Last Modified: | 15 Apr 2021 07:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44075 |
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