Hinkel, Julia and Schmitt, Johannes and Wurm, Michael and Rosenbaum-Fabian, Stefanie and Schwab, Karl Otfried and Jacobsen, Donald W. and Spiekerkoetter, Ute and Fedosov, Sergey N. and Hannibal, Luciana and Gruenert, Sarah C. (2020) Elevated Plasma Vitamin B(12)in Patients with Hepatic Glycogen Storage Diseases. JOURNAL OF CLINICAL MEDICINE, 9 (8): 2326. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Background: Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism affecting the synthesis or breakdown of glycogen in the liver. This study, for the first time, systematically assessed vitamin B(12)status in a large cohort of hepatic GSD patients.Methods: Plasma vitamin B-12, total plasma homocysteine (tHcy) and methylmalonic acid concentrations were measured in 44 patients with hepatic GSDs and compared to 42 healthy age- and gender-matched controls. Correlations of vitamin B(12)status with different disease markers of GSDs (including liver transaminase activities and triglycerides) as well as the vitamin B(12)intake were studied.Results: GSD patients had significantly higher plasma vitamin B(12)concentrations than healthy controls (p= 0.0002). Plasma vitamin B(12)concentration remained elevated in GSD patients irrespective of vitamin B(12)intake. Plasma vitamin B(12)concentrations correlated negatively with triglyceride levels, whereas no correlations were detected with liver transaminase activities (GOT and GPT) in GSD patients. Merging biomarker data of healthy controls and GSD patients showed a positive correlation between vitamin B(12)status and liver function, which suggests complex biomarker associations. A combined analysis of biomarkers permitted a reliable clustering of healthy controls versus GSD patients.Conclusions: Elevated plasma concentration of vitamin B-12(irrespective of B(12)intake) is a common finding in patients with hepatic GSD. The negative correlation of plasma vitamin B(12)with triglyceride levels suggests an influence of metabolic control on the vitamin B(12)status of GSD patients. Elevated vitamin B(12)was not correlated with GOT and GPT in our cohort of GSD patients. Merging of data from healthy controls and GSD patients yielded positive correlations between these biomarkers. This apparent dichotomy highlights the intrinsic complexity of biomarker associations and argues against generalizations of liver disease and elevated vitamin B(12)in blood. Further studies are needed to determine whether the identified associations are causal or coincidental, and the possible impact of chronically elevated vitamin B(12)on GSD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BOVINE SERUM-ALBUMIN; METHYLMALONIC ACID; INTRINSIC-FACTOR; HYPERVITAMINEMIA B12; LIPID-METABOLISM; COBALAMIN; DEFICIENCY; FOLATE; AGE; HOMOCYSTEINE; glycogen storage disease; glycogen; vitamin B-12; cobalamin; liver transaminases; vitamin B(12)intake |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Mar 2021 13:48 |
| Last Modified: | 17 Mar 2021 13:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44082 |
Actions (login required)
 |
View Item |
