Brandstetter, Susanne and Roth, Samra and Harner, Susanne and Buntrock-Doepke, Heike and Toncheva, Antoaneta A. and Borchers, Natascha and Gruber, Rudolf and Ambrosch, Andreas and Kabesch, Michael (2020) Symptoms and immunoglobulin development in hospital staff exposed to a SARS-CoV-2 outbreak. PEDIATRIC ALLERGY AND IMMUNOLOGY, 31 (7). pp. 841-847. ISSN 0905-6157, 1399-3038
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Background Worldwide, the number of SARS-CoV-2 infections is increasing. Serological immunoglobulin tests may help to better understand the development of immune mechanisms against SARS-CoV-2 in COVID-19 cases and exposed but asymptomatic individuals. The aim of this study was to investigate exposure to SARS-CoV-2, symptoms, and antibody responses in a large sample of healthcare workers following a COVID-19 outbreak. Methods A COVID-19 outbreak among staff members of a major German children's and women's hospital was followed by massive RT-PCR SARS-CoV-2 tests and provided the opportunity to study symptoms, chains of infection, and SARS-CoV-2-specific antibody responses (IgG and IgA) by ELISA. Study participants were classified as COVID-19 cases, and persons with close, moderate, or no exposure to SARS-CoV-2 in the clinical setting, respectively. Results Out of 201 study participants, 31 were COVID-19 cases. While most study participants experienced many symptoms indicative for SARS-CoV-2 infection, anosmia and coughing were remarkably more frequent in COVID-19 cases. Approximately 80% of COVID-19 cases developed some specific antibody response (IgA and IgG) approximately 3 weeks after onset of symptoms. Subjects in the non-COVID-19 groups had also elevated IgG (1.8%) and IgA values (7.6%) irrespective of contact history with cases. Conclusion We found that a significant number of diseased did not develop relevant antibody responses three weeks after symptom onset. Our data also suggest that exposure to COVID-19 positive co-workers in a hospital setting is not leading to the development of measurable immune responses in a significant proportion of asymptomatic contact persons.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; antibody response; COVID-19 outbreak; COVID-19 outbreak; COVID-19 pandemic; healthcare workers; immunoglobulin development; infection chain; SARS-CoV-2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2021 07:15 |
| Last Modified: | 22 Mar 2021 07:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44375 |
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