Hasler, Daniele and Meister, Gunter and Fischer, Utz (2021) Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism. RNA BIOLOGY, 18 (2). pp. 290-303. ISSN 1547-6286, 1555-8584
Full text not available from this repository. (Request a copy)Abstract
La and La-related proteins (LARPs) are characterized by a common RNA interaction platform termed the La module. This structural hallmark allows LARPs to pervade various aspects of RNA biology. The metazoan LARP7 protein binds to the 7SK RNA as part of a 7SK small nuclear ribonucleoprotein (7SK snRNP), which inhibits the transcriptional activity of RNA polymerase II (Pol II). Additionally, recent findings revealed unanticipated roles of LARP7 in the assembly of other RNPs, as well as in the modification, processing and cellular transport of RNA molecules. Reduced levels of functional LARP7 have been linked to cancer and Alazami syndrome, two seemingly unrelated human diseases characterized either by hyperproliferation or growth retardation. Here, we review the intricate regulatory networks centered on LARP7 and assess how malfunction of these networks may relate to the etiology of LARP7-linked diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | C-TERMINAL DOMAIN; 7SK SNRNP COMPLEX; HUMAN LA PROTEIN; P-TEFB; TRANSCRIPTION ELONGATION; CHAPERONE ACTIVITY; STRUCTURAL BASIS; INTELLECTUAL DISABILITY; ALAZAMI SYNDROME; RIBOSOMAL-RNA; LARP7; La-related protein; Alazami syndrome; 7SK RNA; P-TEFb; MePCE; U6 snRNA; snoRNA; telomerase; RNA-binding protein; RNP |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Apr 2021 09:54 |
| Last Modified: | 09 Apr 2021 09:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44420 |
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