Schiltz, Daniel and Tschernitz, Sebastian and Ortner, Christine and Anker, Alexandra and Klein, Silvan and Felthaus, Oliver and Biermann, Niklas and Schreml, Julia and Prantl, Lukas and Schreml, Stephan (2020) Adipose Tissue in Multiple Symmetric Lipomatosis Shows Features of Brown/Beige Fat. AESTHETIC PLASTIC SURGERY, 44 (3). pp. 855-861. ISSN 0364-216X, 1432-5241
Full text not available from this repository. (Request a copy)Abstract
Introduction Multiple symmetric lipomatosis (MSL) (syn.: Launois-Bensaude Syndrome, benign symmetric lipomatosis) is a rare disease of fatty tissue. The pathophysiology of MSL still remains unclear, although several approaches have been described in order to understand it. Beside morphological characteristics and some molecular cell biological approaches, little is known about the histological and immunohistochemical characterization of adipose tissue from patients with MSL. Methods From the 45 patients with MSL in our database, 10 were included in the study. Fat tissue samples were collected from affected and unaffected areas. The forearm served as a control area as this area is not affected in MSL. The specimens were analyzed after selected stainings were taken (hematoxylin-eosin = HE, Elastica van Gieson, Ladewig, CD200, CIDEA, myf5, p107, Prdm16, Sca-1, syndecan, UCP1, MAC387, Glut4). Results In patients suffering from MSL, no macroscopic or microscopic morphological difference could be found between affected and unaffected adipose tissue in HE stainings. The majority of samples showed positivity for UCP1 (9/10 clinically affected tissues, 7/10 clinically unaffected tissues) and CD200. Conclusion Marker profiles support the hypothesis that affected adipose tissue derives from brown or beige adipose tissue rather than from white fat.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UNCOUPLING PROTEIN; LAUNOIS-BENSAUDE; BROWN ADIPOCYTE; Multiple symmetric lipomatosis (MSL); Morbus Madelung; Launois-Bensaude syndrome; Adipocytes; Brown fat; Beige fat |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Mar 2021 12:01 |
| Last Modified: | 22 Mar 2021 12:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/44484 |
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