Feder, Susanne and Haberl, Elisabeth M. and Spirk, Marlen and Weiss, Thomas S. and Wiest, Reiner and Buechler, Christa (2020) Pentraxin-3 is not related to disease severity in cirrhosis and hepatocellular carcinoma patients. CLINICAL AND EXPERIMENTAL MEDICINE, 20 (2). pp. 289-297. ISSN 1591-8890, 1591-9528
Full text not available from this repository. (Request a copy)Abstract
The acute-phase protein pentraxin-3 (PTX3) is a component of the innate immune system. Inflammation and tissue injury increased PTX3 in the injured liver, and accordingly, circulating PTX3 was induced in patients with chronic liver diseases. In the present study, PTX3 protein was determined in systemic, hepatic, and portal vein plasma of patients with liver cirrhosis to assess a possible association between hepatic PTX3 release and extent of liver injury. However, PTX3 levels were not related to disease severity. Of note, portal PTX3 levels were higher than concentrations in the hepatic vein. PTX3 in the hepatic and portal veins was negatively correlated with factor V, antithrombin 3, and prothrombin time. PTX3 did neither correlate with C-reactive protein nor galectin-3 or resistin, whereby the latter two proteins are associated with hepatic injury. PTX3 levels were not changed in cirrhosis patients with ascites or varices and did not correlate with the hepatic venous pressure gradient. Likewise, serum PTX3 was not correlated with histological steatosis, inflammation, or fibrosis stage in patients with hepatocellular carcinoma (HCC). Moreover, PTX3 was not associated with tumor node metastasis classification in HCC. Above all, PTX3 increased in hepatic, portal, and systemic blood immediately after transjugular intrahepatic portosystemic shunt (TIPS). Higher PTX3 in portal than hepatic vein plasma and further increase after TIPS suggests that the liver eliminates PTX3 from the circulation. In summary, PTX3 is not of diagnostic value in cirrhosis and HCC patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATES TISSUE FACTOR; C-REACTIVE PROTEIN; PORTAL-HYPERTENSION; LIVER-CIRRHOSIS; PLASMA-LEVELS; PTX3; INFLAMMATION; COMPLICATIONS; COAGULATION; EXPRESSION; MELD score; Ascites; Prothrombin time; Varices; Liver cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2021 07:19 |
| Last Modified: | 30 Mar 2021 07:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45084 |
Actions (login required)
 |
View Item |
