Sinner, Barbara and Banas, Miriam and Brunete-Lorenzo, Clara and Zant, Robert and Knoppke, Birgit and Scherer, Marcus N. and Graf, Bernhard M. and Lunz, Dirk (2020) Acute Kidney Injury and Renal Regional Oxygen Saturation During Pediatric Liver Transplantation. ANNALS OF TRANSPLANTATION, 25: UNSP e9197. ISSN 1425-9524,
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Background: Kidney injury is a complication among children undergoing liver transplantation (pLTx). Cystatin C serum con- centration seems to be superior to creatinine-based determination of kidney injury in adults and children. Nearinfrared spectroscopy (NIRS) technology provides non-invasive and real-time measurement of renal tissue oxygenation. Here, we compared renal tissue oximetry (rSrO(2)) with conventional diagnostic criteria cystatin C and creatinine concentration in children undergoing pLTx. Material/Methods: rSrO(2) was measured intraoperatively in children undergoing pLTx over the left kidney, and was statistically com- pared with pre- and postoperative serum creatinine and cystatin C concentrations. Results: rSrO(2) was affected by hemoglobin concentration, bilirubin concentration, and FiO(2). Statistical analysis dem- onstrated that rSrO(2) was significantly reduced in children with preoperative pathologic increased cystatin C concentrations compared to children without (63.7 +/- 4.3 vs. 53.4 +/- 4.9, p<0.05). We did not detect a significant difference in rSrO(2) between children who developed postoperative renal impairment, either determined by increased postoperative cystatin C concentration, creatinine concentration, or the pRIFLE criteria. lntraoperative increase or decrease in rSrO(2) did not predict the development of postoperative kidney injury. Conclusions: In children with liver failure undergoing pLTx, a preoperative decrease in rSrO(2) indicates compromised renal function. However, intraoperative rSrO(2) is not predictive of postoperative kidney injury.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEAR-INFRARED SPECTROSCOPY; CYSTATIN-C; CHILDREN; DISEASE; ASSOCIATION; BIOMARKERS; OUTCOMES; Acute Kidney Injury; Liver Transplantation; Pediatrics; Spectroscopy, Near-Infrared |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Chirurgie Medicine > Abteilung für Nephrologie Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Apr 2021 08:08 |
| Last Modified: | 01 Apr 2021 08:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45311 |
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