Eichner, A. and Holzmann, T. and Eckl, D. B. and Zeman, F. and Koller, M. and Huber, M. and Pemmerl, S. and Schneider-Brachert, W. and Baeumler, W. (2020) Novel photodynamic coating reduces the bioburden on near-patient surfaces thereby reducing the risk for onward pathogen transmission: a field study in two hospitals. JOURNAL OF HOSPITAL INFECTION, 104 (1). pp. 85-91. ISSN 0195-6701, 1532-2939
Full text not available from this repository. (Request a copy)Abstract
Background: Near-patient surfaces are recognized as a source for hospital-acquired infections. Such surfaces act as reservoirs for microbial contamination by which pathogens can be transmitted from colonized or infected patients to susceptible patients. Routine disinfection of surfaces only results in a temporal elimination of pathogens, and recontamination inevitably occurs shortly between disinfections. Aim: A novel antimicrobial coating based on photodynamics was tested under laboratory conditions and subsequently in a field study in two hospitals under real-life conditions. Methods: Identical surfaces received a photodynamic or control coating. Bacterial counts [colony-forming units (cfu)/cm(2)) were assessed regularly for up to 6 months. Findings: The laboratory study revealed a mean reduction of several human pathogens of up to 4.0 +/- 0.3 log(10). The field study in near-patient environments demonstrated mean bacterial values of 6.1 +/- 24.7 cfu/cm(2) on all control coatings. Photodynamic coatings showed a significantly lower mean value of 1.9 +/- 2.8 cfu/cm(2) (P<0.001). When considering benchmarks of 2.5 cfu/cm(2) or 5 cfu/cm(2), the relative risk for high bacterial counts on surfaces was reduced by 48% (odds ratio 0.38, P<0.001) or 67% (odds ratio 0.27, P<0.001), respectively. Conclusion: Photodynamic coatings provide a significant and lasting reduction of bacterial counts on near-patient surfaces, particularly for high bacterial loads, in addition to routine hygiene. The promising results of this proof-of-concept study highlight the need for further studies to determine how this novel technology is correlated with the frequency of hospital-acquired infections. (C) 2019 Published by Elsevier Ltd on behalf of The Healthcare Infection Society.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BACTERIAL-RESISTANCE; SILVER; NANOPARTICLES; Antimicrobial surface; Photodynamic coating; Decontamination; Pathogen transmission; Hospital-acquired infections |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2021 09:29 |
| Last Modified: | 08 Apr 2021 09:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45546 |
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