Schmidt, Daniel and Grosse, Jirka and Mayr, Roman and Burger, Maximilian and Hellwig, Dirk (2021) Dose estimates of occupational radiation exposure during radioguided surgery of Tc-99m-PSMA-labeled lymph nodes in recurrent prostate cancer. NUKLEARMEDIZIN-NUCLEAR MEDICINE, 60 (06). pp. 425-433. ISSN 0029-5566, 2567-6407
Full text not available from this repository. (Request a copy)Abstract
Aim [Tc-99m]Tc-PSMA-based radioguided surgery (TPRS) represents a curative approach for localized relapse of prostate cancer. For its simplified regulatory permission, the radiation protection authorities require a Tc-99m-activity below the exemption limit of 10MBq at the time of surgery. Our aim was to determine the optimal amount of radioactivity (OAR) to comply with that limit and to estimate the maximum number of TPRS procedures per year and surgeon without triggering the full monitoring obligations. Methods In this retrospective study, a dose rate meter was calibrated using measurements on phantoms and from recently injected (1 min p. i.) patients to determine the activity in the patient from measured dose rates. The effective half-life of Tc-99m- PSMA- I&S in patients was determined from repeated dose rate measurements to estimate dose parameters of relevance for radiation protection. External exposures of the surgeons were measured with personal dosimeters calibrated in H-p(10). The surgeon's finger dose H-p(0.07) is estimated from radioactivity measured in resected lymph nodes. Potenzial incorporations were estimated for an activity of 10MBq. Results From the first 6 subsequent patients, an effective half-life of 4.15 h was observed. Assuming an operation time 24 h p. i., the OAR was 550MBq. Operations lasting in average 2 h in a distance of 0.25m to the patient imply a body dose for surgeons of 4.16 mu Sv per procedure. Based on these estimates, the surgeon's H-p(10) is less than 1mSv per year with up to 241 operations per year. H-p(0.07) and potential incorporation of activity do not lead to further limitations. Summary All radiation protection regulations are met with adherence to OAR recommended here without triggering the full monitoring obligations fromradiation protection regulations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THERAPY; prostate-specific membrane antigen; prostate cancer; radioguided surgery; theragnostic; radiation protection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nuklearmedizin Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Aug 2022 09:25 |
| Last Modified: | 09 Aug 2022 09:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46213 |
Actions (login required)
 |
View Item |
