Biebl, Ariane and Muendlein, Axel and Kinz, Elena and Drexel, Heinz and Kabesch, Michael and Zenz, Werner and Elling, Roland and Mueller, Christoph and Keil, Thomas and Lau, Susanne and Simma, Burkhard (2015) Confirmation of Host Genetic Determinants in the CFH Region and Susceptibility to Meningococcal Disease in a Central European Study Sample. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 34 (10). pp. 1115-1117. ISSN 0891-3668, 1532-0987
Full text not available from this repository. (Request a copy)Abstract
Background: Invasive meningococcal disease (IMD) is a leading cause of meningitis and severe sepsis in children and adolescents. Genetic factors are important in determining the susceptibility to and outcome of IMD. Recently, a genome-wide association study from the United Kingdom showed significant associations of single-nucleotide polymorphisms within complement factor H (CFH; rs1065489) and in CFH-related protein 3 (rs426736) with susceptibility of IMD. We report data of a genetic replication study in Central European children. Methods: The study was conducted as a retrospective case-reference study involving 248 patients with confirmed diagnosis of IMD from Austria and Germany and 835 healthy reference individuals from a multicenter German birth cohort. Results: Carriers of the minor alleles of rs1065489 and rs426736 were at lower risk of IMD [allelic odds ratio = 0.60 (0.44-0.82); P = 0.001 and 0.61 (0.45-0.83); P = 0.001]. Also, 2 major haplotypes (GT and TC) derived from the 2 single-nucleotide polymorphisms were significantly associated with IMD (P = 0.001 and P = 0.003, respectively). Conclusions: The consistency of the results between the genome-wide association study and our study population strengthens the association of CFH polymorphisms to the susceptibility of IMD. Our results support the conclusion that CFH is a critical determinant in acquiring meningococcal disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MANNOSE-BINDING LECTIN; INFLAMMATORY RESPONSE SYNDROME; NEISSERIA-MENINGITIDIS; HAPLOTYPE RECONSTRUCTION; VACCINE; ASSOCIATION; COMPLEMENT; POLYMORPHISMS; EPIDEMIOLOGY; MANAGEMENT; meningococcal disease; CFH; genetics; SNP; children |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jun 2019 07:27 |
| Last Modified: | 06 Jun 2019 07:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4654 |
Actions (login required)
 |
View Item |
