Strack, Christina and Bauer, Susanne and Hubauer, Ute and Uecer, Ekrem and Birner, Christoph and Luchner, Andreas and Maier, Lars and Jungbauer, Carsten (2021) N-acetyl-ss-D-glucosaminidase is predictive of mortality in chronic heart failure: a 10-year follow-up. BIOMARKERS IN MEDICINE, 15 (13). pp. 1143-1154. ISSN 1752-0363, 1752-0371
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Aim: The study focused on biomarkers of kidney injury as predictors of mortality in patients with chronic heart failure (CHF) in a long-term follow-up (median 104 months). Methods/results: KIM-1, NAG and NGAL were assessed from urine, NT-proBNP from blood samples. 149 patients (age 62 +/- 12 years) with CHF (mean EF 30% [IQR 24-40%]) were enrolled. 79 (53%) patients died. Cox regression analysis revealed Log2NAG (HR: 1.46, CI: 1.12-1.89), Log2KIM-1 (HR: 1.23, CI: 1.02-1.49) and Log2NT-proBNP (HR: 1.50, CI: 1.32-1.72) as significant predictors of all-cause mortality as opposed to Log2NGAL (HR: 1.04, CI: 0.90-1.20). Log2NAG remained a significant predictor of all-cause mortality in a multivariate Cox regression model but lost its predictive value in combination with Log2NT-proBNP. Conclusion: The 10-year follow-up suggests NAG as a predictive tubular marker in CHF patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GELATINASE-ASSOCIATED LIPOCALIN; KIDNEY INJURY MOLECULE-1; CARDIOVASCULAR-DISEASE; RENAL-INSUFFICIENCY; EUROPEAN-SOCIETY; TUBULAR DAMAGE; YOUDEN INDEX; BIOMARKERS; ASSOCIATION; RISK; cardiorenal syndrome; chronic heart failure; KIM-1; NAG; NGAL |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Sep 2022 08:04 |
| Last Modified: | 06 Sep 2022 08:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46662 |
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