Romani-Perez, Marina and Lopez-Almela, Inmaculada and Bullich-Vilarrubias, Clara and Rueda-Ruzafa, Lola and Gomez Del Pulgar, Eva M. and Benitez-Paez, Alfonso and Liebisch, Gerhard and Antonio Lamas, Jose and Sanz, Yolanda (2021) Holdemanella biformis improves glucose tolerance and regulates GLP-1 signaling in obese mice. FASEB JOURNAL, 35 (7): e21734. ISSN 0892-6638, 1530-6860
Full text not available from this repository. (Request a copy)Abstract
Impaired glucose homeostasis in obesity is mitigated by enhancing the glucoregulatory actions of glucagon-like peptide 1 (GLP-1), and thus, strategies that improve GLP-1 sensitivity and secretion have therapeutic potential for the treatment of type 2 diabetes. This study shows that Holdemanella biformis, isolated from the feces of a metabolically healthy volunteer, ameliorates hyperglycemia, improves oral glucose tolerance and restores gluconeogenesis and insulin signaling in the liver of obese mice. These effects were associated with the ability of H. biformis to restore GLP-1 levels, enhancing GLP-1 neural signaling in the proximal and distal small intestine and GLP-1 sensitivity of vagal sensory neurons, and to modify the cecal abundance of unsaturated fatty acids and the bacterial species associated with metabolic health. Our findings overall suggest the potential use of H biformis in the management of type 2 diabetes in obesity to optimize the sensitivity and function of the GLP-1 system, through direct and indirect mechanisms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHAIN FATTY-ACIDS; PEPTIDE-1 SECRETION; GUT-MICROBIOME; DIET; RECEPTORS; IMMUNE; glucagon-like peptide 1; gut microbiota; Holdemanella biformis; obesity; type 2 diabetes; vagal afferent neurons |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Sep 2022 14:16 |
| Last Modified: | 13 Sep 2022 14:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47363 |
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