Benitez-Paez, Alfonso and Hess, Anne Lundby and Krautbauer, Sabrina and Liebisch, Gerhard and Christensen, Lars and Hjorth, Mads F. and Larsen, Thomas Meinert and Sanz, Yolanda (2021) Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men. MOLECULAR NUTRITION & FOOD RESEARCH, 65 (8): 2000996. ISSN 1613-4125, 1613-4133
Full text not available from this repository. (Request a copy)Abstract
Scope Dietary-based strategies are regularly explored in controlled clinical trials to provide cost-effective therapies to tackle obesity and its comorbidities. The article presents a complementary analysis based on a multivariate multi-omics approach of a caloric restriction intervention (CRD) with fiber supplementation to unveil synergic effects on body weight control, lipid metabolism, and gut microbiota. Methods and results The study explores fecal bile acids (BAs) and short-chain fatty acids (SCFAs), plasma BAs, and fecal shotgun metagenomics on 80 overweight participants of a 12-week caloric restriction clinical trial (-500 kcal day(-1)) randomly allocated into fiber (10 g day(-1) inulin + 10 g day(-1) resistant maltodextrin) or placebo (maltodextrin) supplementation groups. The multi-omic data integration analysis uncovered the benefits of the fiber supplementation and/or the CRD (e.g., increase of Parabacteroides distasonis and fecal propionate), showing sex-specific effects on either adiposity and fasting insulin; effects thought to be linked to changes of specific gut microbiota species, functional genes, and bacterially produced metabolites like SCFAs and secondary BAs. Conclusions This study identifies diet-microbe-host interactions helping to design personalised interventions. It also suggests that sex perspective should be considered routinely in future studies on dietary interventions efficacy. All in all, the study uncovers that the dietary intervention is more beneficial for women than men.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | dietary fiber; gut microbiome; inulin; metabolomics; multi-omics; obesity; resistant maltodextrin; weight loss |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Sep 2022 05:41 |
| Last Modified: | 14 Sep 2022 05:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47670 |
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