Pereira, Catarina and Mazein, Alexander and Farinha, Carlos M. and Gray, Michael A. and Kunzelmann, Karl and Ostaszewski, Marek and Balaur, Irina and Amaral, Margarida D. and Falcao, Andre O. (2021) CyFi-MAP: an interactive pathway-based resource for cystic fibrosis. SCIENTIFIC REPORTS, 11 (1): 22223. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by more than 2100 mutations in the CF transmembrane conductance regulator (CFTR) gene, generating variability in disease severity among individuals with CF sharing the same CFTR genotype. Systems biology can assist in the collection and visualization of CF data to extract additional biological significance and find novel therapeutic targets. Here, we present the CyFi-MAP-a disease map repository of CFTR molecular mechanisms and pathways involved in CF. Specifically, we represented the wild-type (wt-CFTR) and the F508del associated processes (F508del-CFTR) in separate submaps, with pathways related to protein biosynthesis, endoplasmic reticulum retention, export, activation/inactivation of channel function, and recycling/degradation after endocytosis. CyFi-MAP is an open-access resource with specific, curated and continuously updated information on CFTR-related pathways available online at . This tool was developed as a reference CF pathway data repository to be continuously updated and used worldwide in CF research.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSMEMBRANE CONDUCTANCE REGULATOR; AIRWAY SURFACE LIQUID; PROTEIN-KINASE-C; QUALITY-CONTROL; CFTR; TRAFFICKING; ACTIVATION; BIOLOGY; PHOSPHORYLATION; WIKIPATHWAYS; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Sep 2022 06:14 |
| Last Modified: | 21 Sep 2022 06:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/47742 |
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